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The emerging role of mammalian target of rapamycin inhibitors in the treatment of sarcomas

✍ Scribed by Sushma Vemulapalli; Alain Mita; Yesid Alvarado; Kamalesh Sankhala; Monica Mita

Book ID: 107384417
Publisher: Springer-Verlag
Year: 2011
Tongue: English
Weight: 225 KB
Volume: 6
Category: Article
ISSN: 1776-2596
DOI: 10.1007/s11523-011-0179-4

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## Abstract Mammalian target of rapamycin (mTOR) is a protein serine‐threonine kinase that functions as a central element in signaling pathway involved in control of cell growth and proliferation. mTOR exists in at least two distinct multi‐protein complexes, mTORC1 and mTORC2. mTOR kinase controls