𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The mammalian target of rapamycin pathway and its role in molecular nutrition regulation

✍ Scribed by Jun Lian; Xiang-Hua Yan; Jian Peng; Si-Wen Jiang

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
925 KB
Volume
52
Category
Article
ISSN
1613-4125

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Mammalian target of rapamycin (mTOR) is a protein serine‐threonine kinase that functions as a central element in signaling pathway involved in control of cell growth and proliferation. mTOR exists in at least two distinct multi‐protein complexes, mTORC1 and mTORC2. mTOR kinase controls the translation machinery, in response to nutrients and growth factors, via activation of p70 ribosomal S6 kinase and inhibition of eukaryotic initiation factor‐4E‐binding protein. In this report, we review the mTOR signaling pathway and its interaction with food intake, insulin resistance, lifespan and adipogenic regulation during the molecular nutrition regulation.

πŸ“œ SIMILAR VOLUMES

Amino acid signaling through the mammali
Amino acid signaling through the mammalian target of rapamycin (mTOR) pathway: Role of glutamine and of cell shrinkage
✍ Claudia Fumarola; Silvia La Monica; Guido G. Guidotti πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 357 KB

## Abstract Mammalian target of rapamycin (mTOR) mediates a signaling pathway that couples amino acid availability to S6 kinase (S6K) activation, translational initiation and cell growth rate, participating to a versatile checkpoint that inspects the energy status of the cell. The pathway is activa

Curcumin inhibits the mammalian target o
Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells
✍ Christopher S. Beevers; Fengjun Li; Lei Liu; Shile Huang πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 French βš– 546 KB

## Abstract Curcumin (diferuloylmethane), a polyphenol natural product of the plant __Curcuma longa__, is undergoing early clinical trials as a novel anticancer agent. However, the anticancer mechanism of curcumin remains to be elucidated. Here we show that curcumin inhibited growth of rhabdomyosar

Expression of an activated mammalian tar
Expression of an activated mammalian target of rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy
✍ Leri S. Faried; Ahmad Faried; Tatsuya Kanuma; Hiroshi Aoki; Takaaki Sano; Tomoko πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 667 KB

## Abstract Alterations of the Akt/mTOR pathway have been observed in numerous types of cancer, thus this pathway represents an exciting new target for molecular therapeutics. We investigated the expression of activated Akt (p‐Akt) and mTOR (p‐mTOR) in patients with adenocarcinoma of the cervix and