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The electrochemistry of antineoplastic furanquinones: Electrochemical properties of benzo[b]naphtho[2,3-d]furan-6,11-dione derivatives

✍ Scribed by P.W. Crawford; E. Carlos; J.C. Ellegood; C.C. Cheng; Q. Dong; D.F. Liu; Y.L. Luo

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
486 KB
Volume
41
Category
Article
ISSN
0013-4686

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✦ Synopsis

The electrochemical reductions of 9 benzo[b]naphtho[2,3-dlfuran-6,l I-dione derivatives in dimethylformamide were investigated. In the aprotic medium the quinones reduced in two successive one-electron steps. The influence of molecular structure on reduction potential is addressed. The reduction process involved a single irreversible two-electron process in the presence of a proton source, occurring via an ECE mechanism. A relationship is observed between reduction potential and reported inhibitory activity against various cancer cell lines. The hydroxyl substituted derivatives exhibit the most positive E,,, values and have generally more potent activities.

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