The Efficient Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones and Their Sulfur Derivatives with H2SO4 Immobilized on Activated Charcoal
✍ Scribed by Dilmaghani, Karim Akbari; Zeynizadeh, Behzad; Parasajam, Hadi
- Book ID
- 115467979
- Publisher
- Taylor and Francis Group
- Year
- 2012
- Tongue
- English
- Weight
- 184 KB
- Volume
- 187
- Category
- Article
- ISSN
- 1042-6507
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## Abstract Functionalized 2,3‐dihydro‐1,3‐thiazin‐4(1H)‐one derivatives have been synthesized by cyclocondensation of 3‐alkyl(aryl)amino‐2‐cyano‐3‐mercaptoacrylamides with aldehydes and ketones under acidic catalysis. 6‐Alkyl(aryl)amino‐5‐cyano‐2,3‐dihy‐ dro‐1,3‐thiazin‐4(1H)‐ones, when treated wi
## Abstract 2‐Chloro‐5‐(chloromethyl)‐pyridine reacted with 3,4‐dihydropyrimidin‐2(1H)‐ones **1** to afford 1‐[6‐aryl‐1‐(6‐chloropyridin‐3‐yl‐methyl)‐2‐(6‐chloropyridin‐3‐yl‐methylthio)‐4‐methyl‐1,6‐dihydropyrimidin‐5‐yl] carboxylates or ethanones **2** in good yields. The structure of the target c