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Convenient synthesis and biological activities of pyridine derivatives of 3,4-dihydropyrimidin-2(1H)-ones

✍ Scribed by Xiao-Fei Zhu; De-Qing Shi

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
249 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

2‐Chloro‐5‐(chloromethyl)‐pyridine reacted with 3,4‐dihydropyrimidin‐2(1H)‐ones 1 to afford 1‐[6‐aryl‐1‐(6‐chloropyridin‐3‐yl‐methyl)‐2‐(6‐chloropyridin‐3‐yl‐methylthio)‐4‐methyl‐1,6‐dihydropyrimidin‐5‐yl] carboxylates or ethanones 2 in good yields. The structure of the target compounds 2 was confirmed by IR, ^1^H NMR, EI‐MS, and elemental analyses, and compound 2a was further characterized by single crystal X‐ray diffraction. The preliminary bioassay indicated that some of the title compounds possess moderate insecticidal and fungicidal activities. J. Heterocyclic Chem., (2011).

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