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The Efficacy of Adefovir Plus Entecavir Combination Therapy in Patients with Chronic Hepatitis B Refractory to Both Lamivudine and Adefovir

โœ Scribed by Cho, Yuri; Lee, Dong Hyeon; Chung, Kwang Hyun; Jin, Eunhyo; Lee, Jeong-Hoon; Cho, Eun Ju; Yu, Su Jong; Kim, Jin Wook; Jeong, Sook Hyang; Yoon, Jung-Hwan; Lee, Hyo-Suk; Kim, Chung Yong; Kim, Yoon Jun


Book ID
121635256
Publisher
Springer US
Year
2012
Tongue
English
Weight
264 KB
Volume
58
Category
Article
ISSN
0163-2116

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This study evaluated the efficacy of adefovir (ADV) plus lamivudine (LAM) or ADV add-on therapy for patients with entecavir (ETV)-refractory hepatitis B infection. Twenty-nine ETVresistant and 8 patients with suboptimal response to ETV were enrolled. Twenty-seven patients received ADV รพ LAM therapy

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Entecavir (ETV) is currently recommended as a rescue therapy purely for adefovir (ADV)resistant chronic hepatitis B virus (HBV) infections. We evaluated the efficacy of ETV in patients who were resistant to lamivudine (LAM)/ADV sequential therapy and in those resistant to LAM monotherapy. Fifty LAM/