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The effects of β-adrenergic agonists on cone systems in the cat eye

✍ Scribed by Y. Uji; G. Niemeyer; U. Gerber

Publisher
Springer-Verlag
Year
1988
Tongue
English
Weight
496 KB
Volume
70
Category
Article
ISSN
0012-4486

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✦ Synopsis

The effects of the fl-adrenergic agonist nylidrin and the fl2-adrenergic agonist clenbuterol on electroretinogram and optic nerve response were studied in the isolated and arterially perfused, light-adapted cat eye. Two cone mechanisms, short wavelength-sensitive and long wavelength-sensitive, were functionally separated by means of intense yellow adaptation. A reversible increase in b-wave amplitude in response to nylidrin or clenbuterol was observed for the cone systems. Both drugs also caused a reversible alteration in configuration of the optic nerve response, mainly a depression of the late components related in time to the changes in the electroretinogram. These observations suggest that fl-adrenergic mechanisms are involved in cone systems. The greater increase in b-wave amplitude on 558-nm stimulation and preliminary evidence for greater increase in sensitivity observed in the V-log I function compared with 439 nm further suggest that the short and long wavelength cone systems are affected differently by fl-adrenergic agonists.

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