✦ LIBER ✦

The effects of titanium and polymethylmethacrylate particles on osteoblast phenotypic stability

✍ Scribed by R. Ramachandran; S.B. Goodman; R.L. Smith

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 157 KB
Volume: 77A
Category: Article
ISSN: 1549-3296
DOI: 10.1002/jbm.a.30649

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✦ Synopsis

Abstract

Wear particles generated following total joint arthroplasty interact with cells at the periprosthetic margin and induce an inflammatory response that contributes to osteolysis, aseptic loosening, and implant failure. This study examined the long‐term effects of particles from two commonly implanted materials, titanium (Ti) and polymethylmethacrylate (PMMA), on cell viability and metabolism over a 21‐day time course, using the human osteoblast‐like cell line MG‐63. Addition of particles was not associated with increased cell death or nitric oxide production at the particle concentration chosen. Collagen production was increased with exposure to titanium particles, whereas alkaline phosphatase and osteocalcin expression remained unchanged following exposure to both types of particles. The data show that titanium but not PMMA particles shifts bone cell metabolism to preferentially produce fibrous tissue rather than bone. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006

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