The effects of calcium phosphate particles on the growth of osteoblasts

✍ Scribed by Sun, Jui-Sheng ;Tsuang, Yang-Hwei ;Liao, Chun-Jen ;Liu, Hwa-Chang ;Hang, Yi-Shiong ;Lin, Feng-Huei

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 181 KB
• Volume: 37
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(19971205)37:3<324::aid-jbm3>3.0.co;2-n

✦ Synopsis

With advances in ceramics technology, calcium changes in cell population. The ALP titer in the culture media phosphate bioceramics have been applied as bone substitutes of the ␤-TCP and HA were quite high in the first 3 days, for several decades. The focus of this work is to elucidate then decreased rapidly between the third and seventh days. the biocompatibility of the particulates of various calcium

The concentrations of PGE 2 in the culture media tested were phosphate cytotoxicities. Four different kinds of calcium quite high on the first day, decreased rapidly to the third phosphate powders, including ␤-tricalcium phosphate (␤-day, and then gradually until the seventh day. The changes TCP), hydroxyapatite (HA), ␤-dicalcium pyrophosphate (␤-in the ␤-DCP and SDCP were quite similar to those of HA DCP), and sintered ␤-dicalcium pyrophosphate (SDCP), and ␤-TCP but much less significant. We conclude that HA were tested by osteoblast cell culture. The results were ana-and ␤-TCP have an inhibitory effect on the growth of osteolyzed by cell count, concentration of transforming growth blasts. The inhibitins effects of the HA and ␤-TCP powders factor-␤1 (TGF-␤1), alkaline phosphatase (ALP), and prosta-on the osteoblast cell cultures possibly are mediated by the glandin E 2 (PGE 2 ) in culture media. The changes were most increased synthesis of PGE 2 . © 1997 John