Effects of calcium phosphate bioceramics on skeletal muscle cells

✍ Scribed by Sun, Jui-Sheng ;Tsuang, Yang-Hwei ;Yao, Chun-Hsu ;Liu, Hwa-Chang ;Lin, Feng-Huei ;Hang, Yi-Shiong

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 425 KB
• Volume: 34
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(199702)34:2<227::aid-jbm12>3.0.co;2-f

✦ Synopsis

With advances in ceramics technology, calcium phosphate

The changes in cell population and TGF-ͱ1 concentration in bioceramics have been applied as bone substitutes. The ef-culture medium of the ͱ-TCP and HA were quite low in the fects of implants on bony tissue have been investigated. The first 3 days of culture, then increased gradually toward the effects upon adjacent skeletal muscles have not been deter-seventh day. The changes in cell population and TGF-ͱ1 mined. The focus of this work is to elucidate the biological concentration in culture medium of the silica, ͱ-DCP, and effects of various calcium phosphate bioceramics on skeletal SDCP were quite similar. They were lower during the first muscles. Four different kinds of powder of calcium phos-day of culture but increased and reached that of the control phate biomaterials including ͱ-tricalcium phosphate (ͱ-medium after 7 days' culture. Most cells on ͱ-TCP and HA TCP), hydroxyapatite (HA), ͱ-dicalcium pyrophosphate (ͱ-diminished in size with radially spread, long pseudopods. DCP) and sintered ͱ-dicalcium pyrophosphate (SDCP), were

We conclude that HA and ͱ-TCP are thought to have an tested by myoblast cell cultures. The results were analyzed inhibitory effect on growth of the myoblasts. The HA and by cell count, cell morphology and concentration of trans-ͱ-TCP may interfere with the repair and regeneration of forming growth factor-ͱ1 (TGF-ͱ1) in culture medium. The injured skeletal muscle after orthopedic surgery. ᭧ 1997 John cell population and TGF-ͱ1 concentration of the control sam-Wiley & Sons, Inc. ple increased persistently as the time of culture increased.