The effects of short-chain fatty acids on colon epithelial proliferation and survival depend on the cellular phenotype
✍ Scribed by Mònica Comalada; Elvira Bailón; Oscar de Haro; Federico Lara-Villoslada; Jordi Xaus; Antonio Zarzuelo; Julio Gálvez
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 368 KB
- Volume
- 132
- Category
- Article
- ISSN
- 1432-1335
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## Abstract Short‐chain fatty acids (SCFAs), namely butyrate, acetate and propionate, originate from the bacterial fermentation of dietaiy fibers and are the predominant anions present in the large bowel. Our study was carried out to investigate the effects of SCFAs on growth of the human adenocarc
## Short-chain (C,-C,) fatty acids account for 80%-70% of the anions in the colon. Acetate (C,) is nontoxic in contrast to C,,,,-C, fatty acids (propionate, butyrate, isobutyrate, valerate, and isovalerate). which induce coma in animals and may be important in the patho-gen& of hepatic coma in hum