𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The effects of proglumide on morphine induced motility changes

✍ Scribed by Nitsan Ben-Horin; Einat Ben-Horin; Hanan Frenk

Publisher
Springer
Year
1984
Tongue
English
Weight
262 KB
Volume
84
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

✦ Synopsis

Proglumide (0.02 mg/kg), a cholecystokinin antagonist, was administered to rats either together with or without morphine (0, 5, 15, or 45 mg/kg). Whereas proglumide in the absence of morphine showed a trend towards enhanced behavioral activation, it potentiated the hypokinesia induced by morphine. These results are consistent with the hypothesis that endogenous cholecystokinin tonically antagonizes opiate modulation of motility, irrespective of whether such modulation is produced by opiates and endogenous or exogenous origin.

πŸ“œ SIMILAR VOLUMES

The effects of chronic morphine treatmen
The effects of chronic morphine treatment on neurotensin-induced antinociception
✍ Daniel Luttinger; Susan K. Burgess; Charles B. Nemeroff; Arthur J. Prange πŸ“‚ Article πŸ“… 1983 πŸ› Springer 🌐 English βš– 411 KB

Previous studies have shown that the opioid antagonist naloxone does not alter neurotensin (NT)-induced antinociception. In the present studies, tolerance to morphine in mice significantly attenuated NT-induced antinociception, but not NT-induced hypothermia. In addition, centrally administered NT i

Effect of negative air ions on morphine-
Effect of negative air ions on morphine-induced changes in the latency of the tail-flick reflex
✍ C. J. Beardwood; P. M. Jordi πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 381 KB

## Abstract Adult male Long‐Evans rats were exposed to negatively charged air ions at high concentrations (7 Γ— 10^5^/cm^3^) for six days. Sham‐exposed rats were treated identically except that the source of ions was not activated. At the end of the exposure, the latency of the tail‐flick reflex was