𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The effects of chronic morphine treatment on neurotensin-induced antinociception

✍ Scribed by Daniel Luttinger; Susan K. Burgess; Charles B. Nemeroff; Arthur J. Prange

Publisher
Springer
Year
1983
Tongue
English
Weight
411 KB
Volume
81
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

✦ Synopsis

Previous studies have shown that the opioid antagonist naloxone does not alter neurotensin (NT)-induced antinociception. In the present studies, tolerance to morphine in mice significantly attenuated NT-induced antinociception, but not NT-induced hypothermia. In addition, centrally administered NT inhibited naloxone-precipitated jumping in morphine-dependent mice. These results indicate complex interactions between NT-induced antinociception and opioid systems.

πŸ“œ SIMILAR VOLUMES

The effect of chronic nicotine treatment
The effect of chronic nicotine treatment on nicotine-induced seizures
✍ Lucinda L. Miner; Allan C. Collins πŸ“‚ Article πŸ“… 1988 πŸ› Springer 🌐 English βš– 463 KB

Tolerance to nicotine occurs in mice after its chronic administration. This tolerance is accompanied by an up-regulation of nicotinic receptors as assessed by the binding of (3H)-nicotine and alpha-(125I)-bungarotoxin (BTX). Past studies (Marks et al. 1983, 1986) have shown that the increase in BTX

Pharmacokinetics and pharmacodynamics of
Pharmacokinetics and pharmacodynamics of morphine-3-glucuronide in rats and its influence on the antinociceptive effect of morphine
✍ Marianne Ekblom; Marie GΓ₯rdmark; Margareta Hammarlund-Udenaes πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 555 KB

In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,

The effects of proglumide on morphine in
The effects of proglumide on morphine induced motility changes
✍ Nitsan Ben-Horin; Einat Ben-Horin; Hanan Frenk πŸ“‚ Article πŸ“… 1984 πŸ› Springer 🌐 English βš– 262 KB

Proglumide (0.02 mg/kg), a cholecystokinin antagonist, was administered to rats either together with or without morphine (0, 5, 15, or 45 mg/kg). Whereas proglumide in the absence of morphine showed a trend towards enhanced behavioral activation, it potentiated the hypokinesia induced by morphine. T