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The effects of phenobarbital, 3-methylcholanthrene and benzo(a)pyrene on the hydrolysis of xenobiotics in the rat

โœ Scribed by Swaraj Kaur; Basheer Ali

Book ID
115777018
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
278 KB
Volume
32
Category
Article
ISSN
0006-2952

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Effects of phenobarbital and 3-methylcho
Effects of phenobarbital and 3-methylcholanthrene pretreatment on the pharmacokinetics and the pharmacodynamics of bumetanide in rats
โœ Young M. Choi; Sun H. Lee; Seong H. Jang; Myung G. Lee ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 653 KB

The effects of pretreatment with the enzyme inducers, phenobarbital (PB) and 3-methylcholanthrene (3-MC), on the pharmacokinetic and pharmacodynamic parameters of bumetanide were examined in rats. The nonrenal clearance (19.3 vs 29.6 ml min-' per kg) of bumetanide increased significantly in PB treat