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The effects of norepinephrine and prostaglandin E1 on pharmacokinetics of lidocaine in isolated perfused rat liver

✍ Scribed by Yasushi Matsuura; Shinichi Nishi; Nobutaka Kariya; Kazuhisa Shimadzu; Akira Asada


Book ID
117172860
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
102 KB
Volume
68
Category
Article
ISSN
0024-3205

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Norepinephrine-induced cholestasis in th
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In this study we examined the effect of pharmacological doses of various a-adrenergic agents on hepatic portal perfusion, organic anion uptake and bile se- cretion using the isolated perfused rat liver. Addition of norepinephrine at portal perfusate concentrations ranging from 0.01 to 100 pmol/L ind