𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The effects of methadone and its role in fatalities

✍ Scribed by John M. Corkery; Fabrizio Schifano; A. Hamid Ghodse; Adenekan Oyefeso

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
129 KB
Volume
19
Category
Article
ISSN
0885-6222

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Methadone is a synthetic opioid, used both as an analgesic in severe pain relief and now mainly in the treatment of opiate dependence. Such use of the drug has increased as its advantages have become widely recognized. There are undesirable outcomes from its greater use, including a substantial market in diverted methadone and a high number of deaths where the drug has been implicated. It is important to understand how and why methadone causes death so that such fatalities can be minimized, and to disseminate such information. This paper presents an overview of the chief effects of methadone on the human body, considering its metabolism, drug interactions and tolerance. The principal mechanisms by which methadone causes death are discussed: respiratory depression, aspiration of vomit, pulmonary oedema, bronchopneumonia, cardiac problems and renal failure. Many such deaths are preventable, if drug interactions and polydrug use are avoided, its longer period of metabolism and individuals' tolerance levels are considered. It is hoped that this paper will (a) help guide health professionals in their management and treatment of patients participating in methadone treatment programmes, and (b) provide some basic information for those dealing with individuals who have consumed methadone. Copyright Β© 2004 John Wiley & Sons, Ltd.

πŸ“œ SIMILAR VOLUMES

The preparation of tritium labeled metha
The preparation of tritium labeled methadone and its metabolites
✍ Herbert H. Seltzman; Steven D. Wyrick; Colin G. Pitt πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 French βš– 430 KB

## Abstract The synthesis and catalytic tritium reduction of 1,2‐dehydro analogs of (‐)‐methadol, (‐)‐α‐acetylmethadol, and (‐)‐α‐acetyl‐N‐normethadol afforded the labeled compounds with high specific activity (44‐60 Ci/ mmole). The use of the homogeneous catalyst (Ο•~3~P)~3~RhCl resulted in specifi

The role of the surviving pancreas in la
The role of the surviving pancreas in late fatalities of acute pancreatitis
✍ N. Maclean πŸ“‚ Article πŸ“… 1977 πŸ› John Wiley and Sons 🌐 English βš– 162 KB

## Abstract The necropsy findings in 3 patients who died between 4 and 14 weeks after episodes of acute pancreatitis are described. The most striking features were the extent of extraperitoneal necrosis and the comparative normality of residual portions of the pancreas. It is suggested that when th

Effect of omeprazole on oral and intrave
Effect of omeprazole on oral and intravenous RS-methadone pharmacokinetics and pharmacodynamics in the rat
✍ M. Angeles Carlos; Patrick Du Souich; Raimundo Carlos; Elena Suarez; John C. Luk πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 150 KB

The effect of omeprazole on oral and intravenous (iv) RS-methadone pharmacokinetics and pharmacodynamics was studied in awake, freely moving rats, which were divided in four groups: oral RS-methadone (3 mg/kg) was given (a) to a control group (CO(oral)) (n = 65) and (b) to an omeprazole pretreated g

Role stress in call centers: Its effects
Role stress in call centers: Its effects on employee performance and satisfaction
✍ Ko de Ruyter; Martin Wetzels; Richard Feinberg πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 207 KB

Call centers have become an important customer access channel as well as an important source of customer-related information. Frequently, call center employees experience role stress as a result of the conflicting demands of the company, supervisors, and customers. In this article, antecedents and c