✦ LIBER ✦

The effects of meclofenoxate on cognitive performance in elderly individuals with memory impairment: A placebo-controlled study

✍ Scribed by Dr. S. J. Harris; J. H. Dowson

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 397 KB
Volume: 1
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.930010204

No coin nor oath required. For personal study only.

✦ Synopsis

Twenty residents with mild to moderate memory impairment probably due to senile dementia of Alzheimer type entered a placebo-controlled, double-blind, crossover trial of meclofenoxate 600 mg administered twice daily for 12 weeks. Nine subjects completed the trial during which various tests of cognitive function, including a paired-associate learning test and a word list recall test, were applied.

There was a trend towards improvement on paired-associate learning performance suggesting a beneficial effect of meclofenoxate but none of the cognitive tests showed statistically significant improvements for meclofenoxate when compared with placebo.

The difficulties in mounting a drug trial of this nature in patients who have early dementia are discussed.

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