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The effects of insulin-like growth factor analogues on survival of cultured cerebral cortex and cerebellar granule neurones

✍ Scribed by S.J. Harper; A.J. Macaulay; R.G. Hill; T. Priestley


Book ID
113128094
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
805 KB
Volume
709
Category
Article
ISSN
0006-8993

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## Abstract Survival signals such as insulin‐like growth factor‐1 (IGF‐1) or membrane depolarization convey their neuronal protective effects through the activation of signaling networks and nuclear factors. In cerebellar granule neurons, IGF‐1 mediates survival primarily through the PI3K/Akt pathw