Methylmercury Antagonizes the Survival-Promoting Activity of Insulin-like Growth Factor on Developing Cerebellar Granule Neurons
β Scribed by Robert F. Bulleit; Hong Cui
- Book ID
- 112266765
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 552 KB
- Volume
- 153
- Category
- Article
- ISSN
- 0041-008X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Survival signals such as insulinβlike growth factorβ1 (IGFβ1) or membrane depolarization convey their neuronal protective effects through the activation of signaling networks and nuclear factors. In cerebellar granule neurons, IGFβ1 mediates survival primarily through the PI3K/Akt pathw
## Abstract Evidence from transgenic mice and cultured cerebellar neurons supports an important role for insulinβlike growth factor I (IGFβI) in the formation of cerebellar cytoarchitecture. To understand IGFβI's function during cerebellar development, we examined the involvement of IGFβI in the pr