Recombinant human bone morphogenetic protein-2 (rhBMP-2) is known to induce orthotopic and ectopic bone formation in vivo. Several in vitro studies using rat or mouse clonal cell lines have shown that rhBMP-2 may be involved in the differentiation of osteoblasts from osteoblast precursor cells or st
The effects of heat on the biological activity of recombinant human bone morphogenetic protein-2
β Scribed by Hiroshi Ohta; Shigeyuki Wakitani; Keiji Tensho; Hiroshi Horiuchi; Shinji Wakabayashi; Naoto Saito; Yukio Nakamura; Kazutoshi Nozaki; Yuuki Imai; Kunio Takaoka
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 655 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0914-8779
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## Abstract Bone morphogenetic protein (BMP)β2 plays an important role in bone growth and regeneration; however, BMPβ2 is easily lost by diffusion through body fluid and has some inhibitory pathways. To address this problem, we previously immobilized recombinant human BMPβ2 (rhBMPβ2) on succinylate
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