The effects of curcumin as a chemoprotective agent against aflatoxin B1 induced toxicity in rats
β Scribed by Amnart Poapolathep; Saranya Poapolathep; Kenji Machii; Hiroyuki Nakayama; Susumu Kumagai
- Book ID
- 119381569
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 75 KB
- Volume
- 189
- Category
- Article
- ISSN
- 0378-4274
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## Abstract Several __in vitro__ studies showed that free radical scavengers possess chemopreventive properties against mycotoxinβinduced cell damage which are at least partially associated with the induction of phase II detoxifying enzymes and antioxidant enzymes like glutathione __S__βtransferase
Coumarin (1,2-benzopyrone), a natural food con-nicity with rat liver S9. When liver S9 from chick stituent, prevents polycyclic aromatic hydrocarbon-embryos pretreated with coumarin was used for aflainduced neoplasms in rats and mice, but has not toxin B 1 bioactivation, mutant frequency and cytotox