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The effects of cryopreservation on red blood cell microvesiculation, phosphatidylserine externalization, and CD47 expression

✍ Scribed by Jelena L. Holovati; Kenneth A. Wong; Jarret M. Webster; Jason P. Acker

Book ID: 109144113
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 342 KB
Volume: 48
Category: Article
ISSN: 0372-1248
DOI: 10.1111/j.1537-2995.2008.01735.x

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**BACKGROUND:** Almost 2 percent of murine blood red blood cells (RBCs) are destroyed each day and are replaced by fresh RBCs generated through the process of erythropoiesis. RBCs to be destroyed are phagocytosed by macrophages in the reticuloendothelial system, especially in the spleen. CD47 molecu