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The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5-HT2 and tryptamine binding sites in rat brain

✍ Scribed by Juorio, A.V.; Li, X.M.; Boulton, A.A.

Book ID
123423666
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
329 KB
Volume
21
Category
Article
ISSN
0306-3623

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Pyrroxan (20 mg/kg, i.p.) , a new potential antianxiety agent, increased brain norepinephrine (NE) turnover in rats, reflecting a possible central e-adrenergic receptor blocking activity, in contrast, chlordiazepoxide (20 mg/kg, i.p.), a widely used antianxiety agent, did not alter the NE turnover.