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The effects of chronic ritanserin treatment on sleep and the neuroendocrine response tol-tryptophan

✍ Scribed by C. Idzikowski; P. J. Cowen; D. Nutt; F. J. Mills

Publisher: Springer
Year: 1987
Tongue: English
Weight: 513 KB
Volume: 93
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00207228

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✦ Synopsis

A previous study has shown that acute administration of the 5-HT2 receptor antagonist ritanserin doubles Slow Wave Sleep (SWS) and increases the prolactin (PRL) response to L-tryptophan (LTP). The present study investigated the effect of repeated ritanserin treatment on sleep, neuroendocrine response to LTP and 5-HT2 platelet receptor binding. After 2 weeks, ritanserin administration SWS was persistently increased but the PRL response to LTP was unchanged. Platelet 5-HT receptor binding was undetectable at the end of ritanserin treatment but recovered 2 weeks after drug withdrawal. The results suggest that ritanserin causes a sustained effect on the 5-HT mechanisms mediating SWS and on platelet 5-HT2 receptors. However, adaptation occurs to its effect on 5-HT-mediated neuroendocrine responses.

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