The effects of chlorpromazine and secobarbital on matching from sample and discrimination tasks in monkeys

✍ Scribed by Eva Bakay Pragay; Allan F. Mirsky; Judith M. Abplanalp

• Publisher: Springer
• Year: 1969
• Tongue: English
• Weight: 650 KB
• Volume: 16
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00403615

✦ Synopsis

Monkeys were trained in the performance of a matching from sample task and in two simultaneous visual discrimination tasks differing in level of difficulty. In the case of the matching task, four doses each of chlorpromazine and of secobarbital were administered to the animals according to a balanced design. The procedure was then replicated. The results of the matching task indicated that chlorpromazine produced many errors of omission and few errors of commission. The latter kind of error as well as other measures of confused responding were seen primarily with secobarbital. In the case of the visual discriminations, seeobarbital produced greater impairment of the more difficult (pattern) task than of the simpler (color) task; chlorpromazine had equivalent effects on the two tasks. The similarity between the secobarbital action and the behavioral consequences of certain cortical lesions in the monkey was discussed.