Effects of single and repeated administration of vigabatrin on the performance of non-epileptic rats in a delayed non-matching to position task

✍ Scribed by Maria Mazurkiewicz; Jouni Sirviö; Paavo Riekkinen Sr.

• Publisher: Elsevier Science
• Year: 1993
• Tongue: English
• Weight: 817 KB
• Volume: 15
• Category: Article
• ISSN: 0920-1211
• DOI: 10.1016/0920-1211(93)90059-g

✦ Synopsis

The present experiments were performed to investigate the effects of single and repeated administration of vigabatrin (gamma-vinyl-GABA), a novel antiepileptic drug, on a working memory task (delayed non-matching to position task) in non-epileptic rats. At doses of 100, 300 and 500 mg/kg single administrations of vigabatrin and 50, 100 and 200 mg/kg repeated administrations, vigabatrin did not affect the choice accuracy in the delayed non-matching to position task employing delays of 0, 1, 2, 4, 8 and 16 s, whereas repeated administration with 300 mg/kg and a single dose of 1000 mg/kg decreased the behavioral activity as compared to saline treatment. Previous studies have shown that at doses of 50-200 mg/kg (daily administration) and 200-1000 mg/kg (single administration) vigabatrin has anticonvulsant activity. The present results suggest that vigabatrin does not markedly impair working memory in the low range of antiepileptic/anticonvulsive doses.