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The Effects of Carbidopa Dose and Time and Route of Administration on Systemic L-Dopa Levels in Rats

โœ Scribed by Paula S. Leppert; Margot Cortese; Joseph A. Fix

Book ID
114421081
Publisher
Springer US
Year
1988
Tongue
English
Weight
925 KB
Volume
05
Category
Article
ISSN
0724-8741

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The effect of carbidopa on plasma and mu
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โœ S. Rose; P. Jenner; Prof. C. D. Marsden ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 518 KB

Administration of L-dopa (L-3,4-dihydroxyphenylalanine) (200 mg/kg p.o.) to rats produced elevated plasma and muscle concentrations of both L-dopa and 3-O-methyldopa (3-OMD). This effect was potentiated by simultaneous administration of carbidopa (25 mg/kg p.o.). Both L-dopa and 3-OMD accumulated in