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Nigrostriatal Dopaminergic Neurons Remain Undamaged in Rats Given High Doses of l-DOPA and Carbidopa Chronically

✍ Scribed by Thomas L. Perry; Voon Wee Yong; Masatoshi Ito; James G. Foulks; Richard A. Wall; David V. Godin; Ronald M. Clavier


Book ID
111173103
Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
331 KB
Volume
43
Category
Article
ISSN
0022-3042

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## Abstract In this study, we have examined the effects of chronic L‐3,4‐dihydroxyphenylalanine (L‐DOPA) administration on the remaining dopaminergic neurons in rats with 6‐hydroxydopamine (6‐OHDA) or buffered FeCl~3~ partial lesions to the nigrostriatal tract. L‐DOPA administration increased the t