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The effects of aldose reductase inhibition on nerve sorbitol and myoinositol concentrations in diabetic and galactosemic rats

โœ Scribed by D.K. Yue; M.A. Hanwell; P.M. Satchell; D.J. Handelsman; J.R. Turtle


Book ID
118948827
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
466 KB
Volume
33
Category
Article
ISSN
1532-8600

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Myo-inositol and sorbitol metabolism in
โœ K. R. W. Gillon; J. N. Hawthorne; D. R. Tomlinson ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer ๐ŸŒ English โš– 756 KB

A possible relationship between increased sorbitol concentration and decreased myo-inositol concentration in peripheral nerves of diabetic rats has been examined. To this end, sorbinil, an aldose reductase inhibitor, was used either to prevent or reverse elevation of nerve sorbitol concentration in