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The effects of aging on dopaminergic neurotransmission: a microPET study of [11C]-raclopride binding in the aged rodent brain

✍ Scribed by E. Hoekzema; R. Herance; S. Rojas; D. Pareto; S. Abad; X. Jiménez; F.P. Figueiras; F. Popota; A. Ruiz; È. Torrent; F.J. Fernández-Soriano; M. Rocha; M. Rovira; V.M. Víctor; J.D. Gispert

Book ID: 116789351
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 439 KB
Volume: 171
Category: Article
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2010.10.012

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Positron emission tomography was used to examine the in vivo binding of [ 11 C]raclopride to D 2 -dopamine (DA) receptors in the striatum of two Cynomolgus monkeys after a single dose of reserpine (1 mg/kg, i.v.). A Scatchard procedure was repeated five times to follow D 2 receptor density and appar