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Effects of the substituted (S)-3-phenylpiperidine (−)-OSU6162 on PET measurements of [11C]SCH23390 and [11C]raclopride binding in primate brains

✍ Scribed by Anna Ekesbo; Richard Torstenson; Per Hartvig; Arvid Carlsson; Clas Sonesson; Nicholas Waters; Joakim Tedroff; Bengt Långström

Book ID
117188227
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
394 KB
Volume
38
Category
Article
ISSN
0028-3908

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Effects of the substituted (S)-3-phenylp
Effects of the substituted (S)-3-phenylpiperidine (−)-OSU6162 on PET measurements in subhuman primates: Evidence for tone-dependent normalization of striatal dopaminergic activity
✍ J. Tedroff; R. Torstenson; P. Hartvig; C. Sonesson; N. Waters; A. Carlsson; H. N 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 90 KB 👁 3 views

Ϫ)-OSU6162 is a substituted (S)-3-phenylpiperidine derivative which exhibits some affinity to the dopamine D 2 receptor family. In vivo, the compound displays a unique normalizing profile on psychomotor activity by an intriguing mixture of stimulatory and inhibitory properties. In the present invest