The effects of 2,3-butanedione monoxime (BDM) on the force-velocity relation in single muscle fibres of the frog
โ Scribed by SUN, Y.-B. ;LOU, F. ;EDMAN, K. A. P.
- Book ID
- 114870772
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 715 KB
- Volume
- 153
- Category
- Article
- ISSN
- 0001-6772
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2,3-butanedione 2-monoxime (BDM, 3-30 mM) decreased twitch force of intact ventricular trabeculae isolated from 19-day embryonic chick hearts in a dose-dependent manner. The responses to BDM were rapid and reversible. In an attempt to determine the cellular basis for the inhibitory effect of BDM, ex
2,3-butanedione 2-monoxime (BDM) inhibits muscle contraction and actomyosin ATPase both in fibres and in solution. It is potentially useful as a tool for exploring weak interactions between actin and myosin. We have examined the effect of BDM on several key steps of the myosin subfragment-1 and acto