2,3-butanedione 2-monoxime (BDM, 3-30 mM) decreased twitch force of intact ventricular trabeculae isolated from 19-day embryonic chick hearts in a dose-dependent manner. The responses to BDM were rapid and reversible. In an attempt to determine the cellular basis for the inhibitory effect of BDM, ex
The effect of 2,3-butanedione monoxime (BDM) on smooth muscle mechanical properties
โ Scribed by C. S. Packer; M. L. Kagan; J. F. Kagan; S. A. Robertson; N. L. Stephens
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 658 KB
- Volume
- 412
- Category
- Article
- ISSN
- 0031-6768
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2,3-butanedione 2-monoxime (BDM) inhibits muscle contraction and actomyosin ATPase both in fibres and in solution. It is potentially useful as a tool for exploring weak interactions between actin and myosin. We have examined the effect of BDM on several key steps of the myosin subfragment-1 and acto
## Abstract We investigated the role of myosin in polymorphonuclear leucocyte (PMN) shape changes, locomotion, and fluid pinocytosis using the myosin inhibitor 2,3 butanedione monoxime (BDM). Treatment of resting spherical PMNs with BDM produced spheroid cells showing small continuous shape changes