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The effect of water deprivation and hypertonic salt injection on the oxygen consumption and plasma NaCl concentration in the albino rat

✍ Scribed by Uri Katz; Arieh Borut; Yosef Sarne

Publisher
Springer
Year
1973
Tongue
English
Weight
490 KB
Volume
339
Category
Article
ISSN
0031-6768

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The effects of temporary water deprivation for 48 h on the pharmacokinetics and pharmacodynamics of bumetanide were examined after intravenous (i.v.) administration of bumetanide, 8mg kg-' to control and water deprived rats (n=7). The values of AUC, t,,, and MRT increased 79.0, 417, and 633 per cent