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Effect of water deprivation and prolonged overheating on distribution of acid mucopolysaccharides in the renal medulla of albino rats

โœ Scribed by T. L. Dubynin

Publisher
Springer US
Year
1969
Tongue
English
Weight
468 KB
Volume
67
Category
Article
ISSN
0007-4888

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The effects of temporary water deprivation for 48 h on the pharmacokinetics and pharmacodynamics of bumetanide were examined after intravenous (i.v.) administration of bumetanide, 8mg kg-' to control and water deprived rats (n=7). The values of AUC, t,,, and MRT increased 79.0, 417, and 633 per cent