The effect of velnacrine on the mixed function oxidase system
β Scribed by M. J. Eccles; T. C. Danbury; J. M. Ford; C. J. C. Roberts
- Publisher
- Springer-Verlag
- Year
- 1997
- Tongue
- English
- Weight
- 563 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0378-7966
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π SIMILAR VOLUMES
A drastic impairment in hepatic mixed-function oxidase (MFO) system was observed in rats 24 h following ip injection of CCl 4 (1.0 ml/kg body weight), as indicated by a decrease in the activities of various microsomal enzymes related to drug metabolism (e.g., aniline hydroxylase, aminopyrine-Ndemeth
The biliary excretion of 3H-pentacaine and its metabolites was studied in rats pretreated with an inducer or inhibitor of mixed-function oxidases. Over one-fourth (25.8 per cent) of a 2 mg kg-' intraportal dose of 3H-pentacaine was excreted in bile in urethaneanaesthetized control rats within 3 h. T