The stability of vitamin BIZ was studied i n aqueous solutions of sorbitol,. glycerin, dextrose, and sucrose. Solutions were kept at 2 5 O , 45", and 100' for periods up t o one hundred and forty days. Vitamin BIZ content was determined spectrophotometrically using an absorption maximum of 361 m p . It was found that vitamin Blz is compatible with sorbitol and glycerin at 2 5 ' and 45 '. Dextrose and sucrose solutions were found to cause the loss of vitamin BIZ in solution. Dextrose was more destructive to the vitamin than was sucrose. ORBITOL, GLYCERIN, dextrose, and sucrose have S been used in oral liquid preparations containing vitamin Blz. It has been reported that sorbitol and glycerin are compatible with vitamin BIZ, while reducing agents such as dextrose and sucrose (after hydrolysis) are not (1,2). However, there is little information available indicating the degree to which dextrose and sucrose cause the loss of vitamin BIZ. This led the authors to carry out studies on the stability of vitamin Blz in solutions containing sorbitol, glycerin, dextrose, and sucrose over a period of time at different temperatures.