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The effect of treatment with ketoconazole on central CRH systems of depressed patients

✍ Scribed by Georgios Paslakis; Olivera Lecei; Günther K. Stalla; Rainer Landgraf; Manfred Uhr; Bettina Hamann; Peter Luppa; Maria Gilles; Isabella Heuser; Michael Deuschle

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
206 KB
Volume
26
Category
Article
ISSN
0885-6222

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✦ Synopsis

Abstract

Objectives

Steroid‐synthesis inhibitors are reported to reduce psychopathology in treatment‐resistant depressed patients.

Methods

We studied the effect of a 3‐week treatment with ketoconazole on the evening plasma concentrations of cortisol, corticosteroid‐binding globulin (CBG), dehydroepiandrosterone‐sulfate (DHEA‐S) and adrenocorticotrope hormone (ACTH) as well as morning cerebrospinal fluid (CSF) concentrations of cortisol, corticotropin‐releasing hormone (CRH) and arginine‐vasopressin (AVP) in six elderly treatment‐resistant depressed patients.

Results

While we found plasma cortisol concentrations to be unchanged, a decline in plasma DHEA‐S concentrations indicated effective steroid‐synthesis inhibition. In morning CSF we found CRH concentrations that did not change.

Conclusions

Our preliminary observations indicate that the treatment of depressed patients with the steroid‐synthesis inhibitor ketoconazole does not lead to a major increase in CSF CRH secretion. Copyright © 2011 John Wiley & Sons, Ltd.

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