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The effect of topoisomerase I inhibitor - camptothecin - on expression of p53 in scleroderma fibroblasts

✍ Scribed by Czuwara, Joanna; Nowicka, Urszula; Uhrynowska, Izabela; Gaciong, Zbigniew; Olszewska, Małgorzata; Majewski, Sławomir; Jabłońska, Stefania; Błaszczyk, Maria; Rudnicka, Lidia

Book ID
119562521
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
183 KB
Volume
16
Category
Article
ISSN
0923-1811

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␤-lapachone and camptothecin are structurally unrelated agents thought to inhibit topoisomerase-I activity through distinct mechanisms. We find that ␤-lapachone is much more potent than camptothecin in inducing acute cytotoxic effects on human malignant glioma cells. Acute cytotoxicity induced by bo