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The effect of tolbutamide and glibenclamide on the incorporation of [3H]leucine and on the conversion of proinsulin to insulin in isolated pancreatic islets

โœ Scribed by H. Schatz; V. Maier; M. Hinz; C. Nierle; E.F. Pfeiffer

Book ID
115903049
Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
258 KB
Volume
26
Category
Article
ISSN
0014-5793

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โœ M. P. Hermans; W. Schmeer; J. C. Henquin ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Springer ๐ŸŒ English โš– 738 KB

Mouse islets were used to study how glucose modulates arginine stimulation of insulin release. At 3 mmol/l glucose, arginine (20 mmol/l) decreased the resting membrane potential of B cells by about 10 mV, but did not evoke electrical activity. This depolarisation was accompanied by a slight but rapi