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The effect of thymine dimers on DNA: DNA hybridization

✍ Scribed by Michael Kahn

Publisher
Wiley (John Wiley & Sons)
Year
1974
Tongue
English
Weight
341 KB
Volume
13
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

DNA from bacteriophage T7 was irradiated at long ultraviolet wavelengths in the presence of silver ions. Such treatment leads to selective production of thymine: thymine dimers in DNA. The DNA was melted and the renaturation rate was determined as a function of thymine dimer content and renaturation temperature. Under β€œnormal” hybridization conditions little change in the renaturation rate was observed even when 30% of the thymine was dimerized. This result is consistent with the view that up to a 15% change in the primary sequence of DNA dose not appreciably change the renaturation rate.

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