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The effect of the selective 5-HT3 receptor agonist on ferret gut motility

✍ Scribed by Yukinori Nagakura; Tetsuo Kiso; Keiji Miyata; Hiroyuki Ito; Kiyoshi Iwaoka; Tokio Yamaguchi


Book ID
117173631
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
124 KB
Volume
71
Category
Article
ISSN
0024-3205

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Several substituted 2-pyridazinyl benzoxazole derivatives (VII), (VIII) and (IX) are prepared and evaluated for their utility as 5-HT 3 receptor agonists. A detailed structure-activity relationship study is presented. The most promising results are obtained for the derivatives (VIIa), (VIId) and (VI