β Scribed by Fuchs, S. Yu. ;Spiegelman, V. S. ;Belitsky, G. A.
No coin nor oath required. For personal study only.
D. melanogaster development was markedly retarded and its survival decreased by larvae treatment with compounds being strong inducers of the cytochrome P-450 2B in mammalsphenobarbital (PB*), perfluorodecaline (PFD), transstilbene oxide (TSO), and triphenyldioxane (TPD). At the same time, the weak inducer hexobarbital or the selective cytochrome P-450 inducer in mice but not in rats 1,4-bis[2-(dichloropyridyl-oxy)lbenzene (DPB) did not affect the larvae development. The cytochrome P-450 1Al inducers benzo(a)anthracene (BA) and fl-naphtoflavone (BNF) were also not effective. The toxicity of phenobarbital was shown to be decreased by the cytochrome P-450 inhibitor piperonyl butoxide by adding 20-hydroxyecdysone or by treatment with aminophylline-the indirect enhancer of ecdysone production in the larval prothoracic gland. The hypothesis of the moulting hormone degradation as the cause of elevated larvae mortality resulting from the induced high mixed function oxidase activity has been discussed.
π SIMILAR VOLUMES
## Abstract A description is given of the gross anatomy of the tracheal system of the larva of Drosophila melanogaster. Comparisons of findings are made with those of Lowne for Calliphora, Wahl for Eristalis, Simms for Hylemyia, Dufour for Sarcophaga, Wandolleck for Platycephala, TrΓ€gΓ₯rdh for Ephyd
## Abstract A study has been made of the growth of the eye anlage, and of the increase in number of the elements of the dioptric system of larvae of Drosophila melanogaster. In newly hatched larvae the eye rudiment grows fast, but slows down later and becomes nearly stationary during the second ha
l a 16 Scheme 4. a) [BuLi. T H E 90 min, -78'C; BzCl, pyridine, 12h, 20-C; 5% Na/Hg. 5h. -20 C. 3 5 % : h) Bu,NE THF, 1 h, 0'C. 85%; c) tiBuLi. CICO,Et, THF, 1 h, ~ 30 C. 8 5 % ; d ) morpholine. THF. 2h, reflux; 60% CH,CO,H, 2h. 5 0 Β°C 75%; e) TBDPSCI. imidazole. DMF. ?d, -60 C, 9 6 % ; f) Ac,O, pyr
The influence of in vivo administration of detergents on the hepatic microsomal cytochrome P-450 system was studied in rat. Male Wistar rats were administered detergents, Emulgen 913 (50 mg or 100 mg kg-' of body weight (B.W.)), or sodium dodecylsulfate (SDS, 25 mg or 50 mg kg-' of B.W.) intraperito