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The effect of the carcinogen 3′-methyl-4-dimethylaminoazobenzene on protein synthesis by rat-liver microsomes

✍ Scribed by Arthur O. Hawtrey; Vera Schirren


Book ID
115791324
Publisher
Elsevier Science
Year
1962
Weight
135 KB
Volume
55
Category
Article
ISSN
0006-3002

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Male inbred Leeds strain rats were given single intragastric doses of 1200 mg/kg of 3'-methyl-4-dimethylaminoazobenzene, autoprotective against liver necrosis and then sacrificed at intervals up to 14 months. About 40 per cent of the animals died, apparently as a result of pancreatic necrosis, betwe