In this study special care was taken to discriminate between the direct effect of ethanol on hepatocarcinogenesis and secondary effects such as choline deficiency or fatty liver. Rats were divided into 2 groups, D and N. Group D was initiated using 3'-Me-DAB, while the control group N was not initia
The effect of liver regeneration in the occurrence of hepatom in rats fed with 3′methyl-4-dimethylaminoazobenzene
✍ Scribed by Goto, A.
- Publisher
- Springer-Verlag
- Year
- 1967
- Tongue
- English
- Weight
- 143 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0435-1339
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Male inbred Leeds strain rats were given single intragastric doses of 1200 mg/kg of 3'-methyl-4-dimethylaminoazobenzene, autoprotective against liver necrosis and then sacrificed at intervals up to 14 months. About 40 per cent of the animals died, apparently as a result of pancreatic necrosis, betwe
The diets that have been employed by investigators in the experimental production of liver cancer in rats with certain oilsoluble dyes, such as 4-dimethylaminoazobenzene, generally have been poor nutritionally in that they restricted the growth of the experimental 400[ ~.-" to A 3501-... / "'~ ,,O,.