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The effect of temperature on ATP levels in cells of an ascitic Hepatoma

โœ Scribed by P. C. T. Jones

Publisher
John Wiley and Sons
Year
1969
Tongue
English
Weight
466 KB
Volume
73
Category
Article
ISSN
0021-9541

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โœฆ Synopsis

The effect of temperature on intracellular ATP levels in cells of the ascitic Hepatoma 129 has been determined using an UV-enzymic method. ATP levels are found to vary inversely with temperature over the range (4"-37"C) studied, and this variation is found to be reversible. An indication of a possible direct correlation of ADP level with temperature was also obtained.

A correlation is deduced between rise i n intracellular ATP level and decrease in cytoplasmic viscosity, both from the present results, and from similar effects recently reported by Landau ('61) for increase i n pressure.

The significance of these observations is discussed with reference to the model for cytoplasmic viscosity proposed by Marsland ('56) and the wider biological significance of this effect is explored.

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