𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The effect of T-lymphocyte ‘clonality’ on the calculated hprt mutation frequency occurring in vivo in humans

✍ Scribed by J.Patrick O'Neill; Janice A. Nicklas; Timothy C. Hunter; Oliver B. Batson; Mark Allegretta; Michael T. Falta; Richard F. Branda; Richard J. Albertini


Book ID
113253000
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
728 KB
Volume
313
Category
Article
ISSN
0165-1161

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Splicing mutations at the HPRT locus in
✍ Anne-May Österholm; Sai-Mei Hou 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 183 KB 👁 3 views

We studied 58 splicing mutations originating in observed. The predicted change in three of the base vivo at the hypoxanthine guanine phosphoribosyl-substitutions would be a stop codon. The tandem transferase (HPRT) locus in T-cells of 30 nonsmoking mutation (CC r TT) occurred at position 550-551, ma

Determination of hprt mutant and mutatio
✍ John Curry; Gabriella T. Rowley; Vera Saddi; David Beare; Jane Cole; Barry W. Gl 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 1004 KB

nine resistant T-lymphocytes were isolated from two blood samples obtained 4 months apart from a 50year-old male subiect. Sixty-six of these mutants were characterized at the DNA sequence level using cDNA. One particular single base substitution was recovered a total of 23 fimes. The majority of T-c

Deletion and insertion in vivo somatic m
✍ Karolyn J. Burkhart-Schultz; Irene M. Jones 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB 👁 2 views

Deletion and insertion mutations have been found to be a major component of the in vivo somatic mutation spectrum in the hypoxanthine phosphoribosyltransferase (hprt) gene of T-lymphocytes. In a population of 172 healthy people (average age, 34; mutant frequency, 10.3 x 10(-6)), deletion/insertion m