We studied 58 splicing mutations originating in observed. The predicted change in three of the base vivo at the hypoxanthine guanine phosphoribosyl-substitutions would be a stop codon. The tandem transferase (HPRT) locus in T-cells of 30 nonsmoking mutation (CC r TT) occurred at position 550-551, ma
The effect of T-lymphocyte ‘clonality’ on the calculated hprt mutation frequency occurring in vivo in humans
✍ Scribed by J.Patrick O'Neill; Janice A. Nicklas; Timothy C. Hunter; Oliver B. Batson; Mark Allegretta; Michael T. Falta; Richard F. Branda; Richard J. Albertini
- Book ID
- 113253000
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 728 KB
- Volume
- 313
- Category
- Article
- ISSN
- 0165-1161
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
nine resistant T-lymphocytes were isolated from two blood samples obtained 4 months apart from a 50year-old male subiect. Sixty-six of these mutants were characterized at the DNA sequence level using cDNA. One particular single base substitution was recovered a total of 23 fimes. The majority of T-c
Deletion and insertion mutations have been found to be a major component of the in vivo somatic mutation spectrum in the hypoxanthine phosphoribosyltransferase (hprt) gene of T-lymphocytes. In a population of 172 healthy people (average age, 34; mutant frequency, 10.3 x 10(-6)), deletion/insertion m