The effect of systemic treatment with 5-fluorouracil on the epidermis of the guinea pig

✍ Scribed by H. Wirth; B. Vollweiler; M. Gloor; U. W. Schnyder

• Book ID: 104777919
• Publisher: Springer-Verlag
• Year: 1978
• Tongue: English
• Weight: 245 KB
• Volume: 263
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00446851

✦ Synopsis

The thymidine labelling index and the mitosis rate (blocked by colcemid) in the basal cell layer of the guinea pig were determined before and during treatment with 5-fluorouracil (1 mg i.p. in 2 day's interval/100 g body weight). Additionally, the epidermal area and thickness and the number and size of cells were measured. 5-Fluorouracil equally reduces the thymidine labelling index and the mitosis rate with the full effect after treatment of at least 22 days. From these findings it is concluded that the S-phase--calculated from the end of the thymidine synthesis--is not altered. Furthermore atrophy of the epidermis runs parallel with the reduction of the 3H thymidine labelling index and the mitosis rate.