To test the scavenging of reactive oxygen species (ROS), we added synovial fluids from patients with rheumatoid arthritis (RA) and osteoarthritis, as well as hyaluronic acid (HA) and its 2 subcomponents, Dglucuronic acid and N-acetyl-D-glucosamine, to 2 ROSgenerating systems, activated neutrophils a
The effect of synovial fluid proteins in the degradation of hyaluronic acid induced by ascorbic acid
β Scribed by Noriko Motohashi; Itsuhiko Mori
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 345 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0162-0134
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## Abstract Degradation of hyaluronic acid (measured viscometrically) by oxygenβderived free radicals (ODFR) generated 1) by autoxidation of ferrous EDTA chelates and 2) enzymatically by xanthine oxidase and hypoxanthine (XO/HX) was studied. Degradation of hyaluronic acid by XO/HX was strongly inhi