Antioxidant activity of synovial fluid, hyaluronic acid, and two subcomponents of hyaluronic acid. synovial fluid scavenging effect is enhanced in rheumatoid arthritis patients

✍ Scribed by Hideki Sato; Terumi Takahashi; Hirotsugu Ide; Toshiyuki Fukushima; Minoru Tabata; Fusao Sekine; Kazuo Kobayashi; Masao Negishi; Yukie Niwa

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 663 KB
• Volume: 31
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780310110

✦ Synopsis

To test the scavenging of reactive oxygen species (ROS), we added synovial fluids from patients with rheumatoid arthritis (RA) and osteoarthritis, as well as hyaluronic acid (HA) and its 2 subcomponents, Dglucuronic acid and N-acetyl-D-glucosamine, to 2 ROSgenerating systems, activated neutrophils and xanthine xanthine oxidase. Synovial fluid from RA patients, HA, and D-glucuronic acid markedly decreased the 0 2 -, H,O,, OH-, and chemiluminescence measured in both systems. HA and synovial fluid, which are known to be susceptible to degradation by excessive ROS in RA patients, also seem to play an active role in protecting articular tissues from oxidative damage. Hyaluoronic acid (HA) is a glucosaminoglycan with a repeating disaccharide structure that is composed of D-glucuronic acid in / 3 1+3 linkage to Nacetyl-D-glucosamine, which in turn, is in p 1+4 From the